O-271 Application of HyFoSy in the assessment of fallopian tube patency compared to HyCoSy and HS; results of a systematic review and meta-analysis

Abstract Study question To assess whether Hystero-salpingo-Foam Sonography (HyFoSy) is an effective and feasible alternative to X-ray Hystero-Salpingo-Graphy (HSG) Hystero-salpingo-Contrast (HyCoSy) in fallopian tube patency assessment. Summary answer HyFoSy demonstrated significantly superior diagnostic sensitivity specificity compared HyCoSy, however only minimal agreement with HSG. What known already Tubal pathology a contributing factor up 35% of infertility cases, fact which renders accurate clinically applicable tubal assessment vital component the workup. Currently, most widely utilized methods are HyCoSy HSG, which, while effective, do possess certain disadvantages. aforementioned test, utilizing specially developed contrast agent, may offer comparable efficacy without associated disadvantages other two methods. design, size, duration Relevant studies were systematically searched for Scopus, Pubmed Web Science online peer-reviewed databases. The resulting assessed based on pre-established inclusion criteria (PICOS format) according PRISMA algorithm systematic reviews. included risk bias using modified version QUADAS-2 tool relevant data was extracted meta-analysis performance conducted. Participants/materials, setting, This analysis from 5 1433 patients, 2336 tubes being eligible inclusion. Data regarding primary outcomes true positive, false negative number patients that used reference test could be calculated. For inter-method agreement, raw method disagreement Cohen’s k values Main results role chance With regard comparison, pooled 87% 69% respectively, difference statistically significant (p = 0.037), 95% 85% < 0.001). Regarding HSG statistic 0.39 ; this interpreted as fair overall between procedure-associated patient pain, 6.5 times more painful (OR 6.57, CI 3.11–13.89) former graded at 5.4 ± 2.5 10-point scale latter 3.1 2.2 0.001), significant. Limitations, reasons caution small available comparative HyFoSy, lack standard comparison observed statistical heterogeneity, have introduced degree if analysis. Wider implications findings less than reliable diagnosing patency, first line reserving its value evaluation abnormal and/or unclear second test. Trial registration not